Bovine viral diarrhea (BVD) or bovine viral diarrhoea , and previously referred to as bovine virus diarrhoea (BVD), is a significant economic disease of cattle that is found in the majority of countries throughout the world. Worldwide reviews of the economically assessed production losses and intervention programs (e.g. eradication programs, vaccination strategies and biosecurity measures) incurred by BVD infection have been published. The causative agent, bovine viral diarrhea virus (BVDV), is a member of the genus Pestivirus of the family Flaviviridae.