Other Names

Mouse Immunoglobulin G ELISA kit

IgG

Background

Mouse immunoglobulin G (IgG) is the main component of immunoglobulin in serum, it is mainly created and secreted by plasma cells in spleen and lymph nodes and exists in the form of monomer. IgG comprises approximately 75% of serum immunoglobulin. Its normal value is in mg/ml in body fluids with 40%-50% distributed in serum and the rest distributed in tissues. Immunoglobulin in the immune serum of human and animals has very dissimilar concentration and structure, there is considerable discrepancy with their composition, structure, size, electric charge, and biological activity, etc.The immunoglobulin comprises about 20-25% of whole serum albumin.  To date, 5 types of immunoglobulin have been isolated and purified in human, mouse and other animals' serum-IgG, IgM, IgA, IgD and IgE. According to the antigenic specificity of γ chain in IgG molecule, mouse IgG is divided into 4 subtypes: IgG1, IgG2a, IgG2b and IgG3.

Mouse IgG can activate complement through classical pathway, its ability to bind complement is IgG2b＞IgG2a＞IgG3, while IgG1 has no ability to bind complement.