Other Names

IgG

Background

Bovine Immunoglobmlin G (IgG) is the major component of immunoglobulin in bovine serum with a molecular weight of about 160 kDa, 40～50% of which are distributed in serum, and the rest are distributed in tissues. IgG is divided into 4 subtypes: IgG1, IgG2, IgG3 and IgG4, and its content in serum is 17-27mg/mL.

Bovine immunoglobulin G (Bovine IgG) is widely used in basic biochemistry, research and teaching, biomedical production fields. The products produced by biotechnological processes, such as the materials used in cells or tissue culture media, all may lead to residual contamination of the finished products. Bovine IgG is often used as a medium to culture mammalian cells in recombinant pharmaceutical production because of it's large amout in fetal bovine serum.

During the production process of recombinant drugs, some of the bovine IgG are removed by process optimization and purification, but some of them may still exist in the some of the recombinant drugs and other finished products.However when these products are used to treat for human or animals, bovine IgG as a sensitizers may cause an immune response, influence human health or even threaten lives at worst. Therefore, the detection of residual bovine IgG is an important process in the quality control of biomedical products.