
人转化生长因子β2(TGFB2)重组蛋白 |
Catalog #: P01T0004 |
Other Names
TGFB2, G-TSF; LDS4; TGF-beta2
Background
TGFβ2 is a multifunctional polypeptide cytokine composed of 442 amino acids. It plays an important role in cell morphology, proliferation, differentiation, embryonic development and angiogenesis, and plays a very key role in the regulation of human immune system. The activated receptor complex signal is transmitted to cells mainly through Smad protein family. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers.
Product Name |
Recombinant TGFB2 Protein |
Species |
Human |
Product Size |
10ug/50ug/100ug/1mg |
Protein sequence |
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIE
AIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR
DLLQEKASRRAAACERERSDEEYYAKE
VYKIDMPPFFPSETVCPVVTTPSGSVGSLCSR
QSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA
SNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDL
TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE
WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEA
RFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPH
LLLMLLPSYRLESQQTNRRKKRALDA
AYCFRNVQDNCCLRPLYIDFKRDLGWKWI
HEPKGYNANFCAGACPYLWSSDTQHSRVL
SLYNTINPEASASPCCVSQDLEPLTILYYIGKTP
KIEQLSNMIVKSCKCS
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Express region |
1-442aa |
Fusion Tag |
6x His-SUMO (N-terminus) |
Molecular Weight |
About 50.6kDa |
Purity |
≥95% SDS-PAGE |
Physical property |
liquid or lyophilized powder |
Reconstitution |
Storage solution: We recommend using PBS or a suitable solvent according to the experimental requirements to prepare 1mg/mL storage solution, aliquot and store at -20 °C.
Working solution: According to the experimental requirement, dilute Storage solution. The working solution can be stored at 4°C for 2-3 weeks after dilution.
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Storage & Stability |
The shelf life of liquid form is 6 months stored at -20 °C /-80 °C.
The shelf life of lyophilized form is 12 months stored at -20 °C /-80 °C.
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Reference
1. 张东勇,仇波,王运杰.胶质瘤治疗的新靶点:TGF-β2.分子诊断与治疗杂志,2013,5(02):123-127.