
人骨形态发生蛋白受体1B型 (BMPR1B) 重组蛋白 |
Catalog #: P01B0012 |
Other Names
BMPR1B, ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
Background
BMPR1B gene, a member of the bone morphogenetic protein (BMP) receptor family, encodes transmembrane serine/threonine kinases, and binds BMPs. BMPs are members of the TGF-beta superfamily and involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Several transcript variants encoding two different isoforms have been found for this gene.
Product Name |
Recombinant BMPR1B Protein |
Species |
Human |
Product Size |
10ug/50ug/100ug/1mg |
Protein sequence |
MGWLEELNWQLHIFLLILLSMHTRANFLDNMLLRSAGKL
NVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICS
TDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPH
QRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLI
SVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESL
RDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGE
VWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHE
NILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDA
KSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNIL
VKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPP
EVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRW
SSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAK
MSESQDIKL
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Express region |
1-532aa |
Fusion Tag |
6x His-SUMO (N-terminus) |
Molecular Weight |
about 60.6kDa |
Purity |
≥95% SDS-PAGE |
Physical property |
liquid or lyophilized powder |
Reconstitution |
Storage solution: We recommend using PBS or a suitable solvent according to the experimental requirements to prepare 1mg/mL storage solution, aliquot and store at -20 °C.
Working solution: According to the experimental requirement, dilute Storage solution. The working solution can be stored at 4°C for 2-3 weeks after dilution.
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Storage & Stability |
The shelf life of liquid form is 6 months stored at -20 °C /-80 °C.
The shelf life of lyophilized form is 12 months stored at -20 °C /-80 °C.
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Reference
1. Mang Tanja, Kleinschmidt Doerr Kerstin, Ploeger Frank, Schoenemann Andreas, Lindemann Sven,Gigout Anne. BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. J Cell Sci. 2020;133(16):jcs246934.