Human Bone Morphogenetic Protein Receptor type 1B (BMPR1B) -v3 protein , Recombinant
Catalog #: P01B0012

 

Other Names

BMPR1B, ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293

 

Background

BMPR1B gene, a member of the bone morphogenetic protein (BMP) receptor family, encodes transmembrane serine/threonine kinases, and binds BMPs. BMPs are members of the TGF-beta superfamily and involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Several transcript variants encoding two different isoforms have been found for this gene.

BMPR1A and BMPR1B have overlapping functions. BMPR1A and BMPR1B are expressed during early chondrogenesis in mice and are necessary for chondrogenesis in vivo and crucial for endochondral ossification. Recent studies suggest that stronger BMPR1B signaling, compared with BMPR1A signaling, prevents chondrocyte hypertrophy and acts as a cartilage stabilizer during joint morphogenesis.