Other Names

Human Receptor Tyrosine Protein Kinase ELISA kit

CD340; EGFR2; HER-2/neu; HER2; NEU; MLN 19; NGL; TKR1; p185; Epidermal Growth Factor Receptor 2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2; Neuro/Glioblastoma Derived Oncogene Homolog

Background

Receptor tyrosine protein kinase (ErbB2) is also known as Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase and also belongs EGF receptors superfamily. ErbB2 is widely expressed in epithelial cells and over-expressed in lung carcinomas. Although HER2 itself lacks ligand binding domain and self inhibition to bind to growth factors, it can form heterodimer with EGF family having ligand binding domain function, which can stabilize ligand binding and enhance enzyme-mediated downstream molecular activation. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays important roles in cell growth, proliferation, differentiation and cancer. It was found that the ErbB2/ErbB3 heterodimer is expressed in the majority of tumor tissues. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system