Catalog #: E03C0989
Sample Type: Biological samples


Other Names

Mouse Claudin 6 ELISA kit

CLDN6; CLDN 6; CLDN-6; Claudin6; Skullin 2; Skullin

Research Area

Signal transduction, Microbiology, Stem cells, Developmental Biology


Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.