SDS
小鼠谷氨酸脱羧酶自身抗体(GAD-Ab)酶联免疫吸附试剂盒
Catalog #: E03G0464
Sample Type: Biological samples

 

Other Names

Mouse Glutamic Acid Decarboxylase autoantibody ELISA kit

GAG-Ab; GST-M3; GST5; GSTB; GSTM3-3; GTM3

Research Area

Microbiology

Background

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.