SDS
小鼠血小板反应蛋白解整合素金属肽酶10(ADAMTS10)酶联免疫吸附试剂盒
Catalog #: E03A0929
Sample Type: Biological samples

 

Other Names

Mouse A disintegrin and metalloproteinase with thrombospondin motifs 10 ELISA kit

WMS; ADAM-TS10

Research Area

Signal transduction, Cell Biology

Background

ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.