SDS
犬转甲状腺素蛋白(PALB)酶联免疫吸附试剂盒
Catalog #: E08T0362
Sample Type: Biological samples

 

Other Names

Canine Transthyretin ELISA kit

TBPA; PA; PLB; ATTR; PALB; Transthyretin; Prealbumin Amyloidosis Type I; Transports Thyroxine and Retinol

Research Area

Neuroscience, Cardiovascular

Background

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.