SDS
大鼠肾素(REN)酶联免疫吸附试剂盒
Catalog #: E02R0022
Sample Type: Biological samples

 

Other Names

Rat Renin ELISA kit

Rat Renin ELISA kit; Renin; angiotensinogenase; REN

Research Area

Cardiovascular, Signal transduction, Metabolism

Background

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.