SDS
大鼠吻素1(KISS1)酶联免疫吸附试剂盒
Catalog #: E02T0490
Sample Type: Biological samples

 

Other Names

Rat Kisspeptin ELISA kit

AXOR12; G protein coupled receptor 54; GPCR54; GPR54; Hypogonadotropin 1; Hypogonadotropin1; KISS1 receptor; KISS1R; Kisspeptins receptor; metastin receptor; KiSS 1 metastasis suppressor; KISS-1; Kisspeptin 1; Kisspeptin 10; Kisspeptin 13; Kisspeptin 14; Kisspeptin; Kisspeptin-10; Kisspeptin-54; Malignant melanoma metastasis suppressor; Metastasis suppressor KiSS 1; Metastasis suppressor KiSS1; Metastin

Research Area

Cell Biology, Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Background

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.