Abstract
OBJECTIVE: To investigate the dynamic changes ofurinary nephrin, and the relationship between itand urinary albumin excretion rate (UAER) in a diabeticrat model, as well the effects of yiqiyangyinhuayutongluorecipe.
METHODS: Diabetic model was induced by highfat diet combined with low-dose Streptozotocin(STZ) in rats. Normal group (NG), model group(MG), and yiqiyangyinhuayutongluo recipe treatedgroup (YHTG) were set. Gastrointestinal Yiqiyangyinhuayutongluorecipe was administered once dailyfor 32 w. At the end of the 2nd w (2w), 8w, 16w, and32w, fasting blood glucose (FBG), UAER and 24h urinarynephrin (U-nephrin) were detected.
RESULTS: Compared with NG, FBG in MG increasednotably (P<0.05). Compared with MG, FBG of YHTGreduced slowly, and the difference was significant(P<0.05) since 16w. U-nephrin and UAER in MG increasedsignificantly from 2w, peaked at 16w, lessenedin different degree at 32w, but were still higherthan NG. The correlation analysis showed thatthere was a significant positive correlation betweenU-nephrin and UAER at different time, thecorrelation coefficient as r>0.9, and P<0.05. Compared
with MG, U-nephrin and UAER in YHTG decreasedmarkedly (P<0.05) except for U-nephrin at
8w.
CONCLUSIONS: U-nephrin and UAER in diabeticrat model have a positive linear correlation. Yiqiyangyinhuayutongluo
recipe can reduce UAER markedly,and preventing the lose of nephrin in urine maybeone of the mechanisms.
© 2012 JTCM. All rights reserved.
Key words: Yiqiyangyinhuayutongluo recipe; Diabetic
nephropathy; Urinary nephrin; Urinary albumin
excretion rate; SD rats