Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome
2012-01-301275
abstract
Aim: The goal of this study was to investigate the association between omentin-1 andcarotid atherosclerosis in patients with metabolic syndrome (MetS).Method: We enrolled randomly 60 MetS patients, evaluated their carotid atherosclerosisemploying ultrasonography and then divided them into two subgroups, MetS with atherosclerosis(MetS + AS) and MetS without atherosclerosis (MetSAS) according to the level of
carotid intima-media thickness (CIMT) and presence of plaque. Stiffness, strain and distensibilitywere calculated.Waistcircumferenceandblood pressure (BP) were measured.Fasting blood sample was collected to determine biochemical indicators and insulin resistanceindex (HOMA-IR). Omentin-1 plasma level was assessed by ELISA. Association ofomentin-1 with CIMT and metabolic markers were studied.
Results: Levels of omentin-1 were lower in MetS than in controls and reduced further inMetS + AScomparedwithMetSAS.Incorrelationanalysis, omentin-1 was negative associatedwith CIMT, stiffness, waist circumference, body mass index (BMI), systolic bloodpressure (SBP), fast blood glucose (FBG), and HOMA-IR.
Conclusions: Omentin-1 is closely related to MetS and might play an important role inatherosclerosis in MetS patients.
Aim: The goal of this study was to investigate the association between omentin-1 andcarotid atherosclerosis in patients with metabolic syndrome (MetS).Method: We enrolled randomly 60 MetS patients, evaluated their carotid atherosclerosisemploying ultrasonography and then divided them into two subgroups, MetS with atherosclerosis(MetS + AS) and MetS without atherosclerosis (MetSAS) according to the level of
carotid intima-media thickness (CIMT) and presence of plaque. Stiffness, strain and distensibilitywere calculated.Waistcircumferenceandblood pressure (BP) were measured.Fasting blood sample was collected to determine biochemical indicators and insulin resistanceindex (HOMA-IR). Omentin-1 plasma level was assessed by ELISA. Association ofomentin-1 with CIMT and metabolic markers were studied.
Results: Levels of omentin-1 were lower in MetS than in controls and reduced further inMetS + AScomparedwithMetSAS.Incorrelationanalysis, omentin-1 was negative associatedwith CIMT, stiffness, waist circumference, body mass index (BMI), systolic bloodpressure (SBP), fast blood glucose (FBG), and HOMA-IR.
Conclusions: Omentin-1 is closely related to MetS and might play an important role inatherosclerosis in MetS patients.
